Ellis, which belongs to the first batch of dual-use resources of medicine and food issued by the Ministry of health. In particular, traditional Chinese medicine has emerged as a potential area of exploration.įructus Gardeniae is the fruit of Rubiaceae plant Gardenia jasminoides J. Hence, the efficacy and acceptability must be taken into consideration for new antidepressant discovery. Although pharmacotherapy for depression has changed into antidepressants with more selective actions, several defects such as the treatment-resistant phenomenon, the delay of drug efficacy, and serious side effects still affect patient outcomes. Various factors contribute to the pathophysiology of depression, including the monoamine hypothesis, hypothalamic-pituitary-adrenal axis changes, neuroplasticity and neurogenesis, and inflammation ( Malhi and Mann, 2018). With a lifetime risk of over 15%, almost one in five people suffers one episode in their lifetime. These results indicated that Zhi-zi-chi decoction exerted a potential antidepressive effect associated with reversing the imbalance of glutathione and oxidative stress in the brain of depressed rats.ĭepression is a common illness that severely increases the burden of disease worldwide and diminishes the quality of life. Combined with our previous study, the antioxidant effect of the glutathione pathway in the antidepressant effect of Zhi-zi-chi decoction was verified from the cellular and animal levels respectively. At the same time, the levels of reactive oxygen species, superoxide dismutase, glutathione reductase, glutathione peroxidase in the brain of depressed rats were measured. The targeted metabolism of the glutathione metabolic pathway was analyzed. 26 differential metabolites and six metabolic pathways related to the antidepressant of Zhi-zi-chi decoction were screened and analyzed. The brain metabolic profile of depressed rats was analyzed by the method of metabolomics based on ultra-performance liquid chromatography-quadrupole/time-of-flight mass. In this study, the animal model of depression was established by chronic unpredictable mild stimulation combined with feeding alone. Our previous research has found that Zhi-Zi-chi decoction can reduce glutamate-induced oxidative stress damage to PC 12 cells, which can exert a neuroprotective effect, and the antidepressant effect of Zhi-Zi-chi decoction was verified in CUMS rat models. However, the research on the antidepressant mechanism and efficacy material basis of Zhi-zi-chi decoction has not been reported yet. As a traditional Chinese medicine, Zhi-zi-chi decoction is utilized to regulate and improve depression. 3Chengdu Institute for Drug Control, Chengdu, Chinaĭepression is one of the main diseases that lead to disability and loss of ability to work.2Shanghai Key Laboratory for Pharmaceutical Metabolite Research, School of Pharmacy, Second Military Medical University, Shanghai, China.1School of Pharmacy, Second Military Medical University, Shanghai, China.Yin Zhang 1,2,3 † Yi-Chao Fang 1,2 † Li-Xun Cui 1,2 † Yue-Tong Jiang 1,2 Yu-Sha Luo 1,2 Wen Zhang 1,2 De-Xun Yu 1,2 Jun Wen 1,2* Ting-Ting Zhou 1,2*
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